Injections for Treating Osteoarthritis of the Knee
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Hyalgan

FAQ Hyalgan
What can I expect from Hyalgan treatment?
Hyalgan has been proven to provide long-lasting relief of OA knee pain. In a published clinical trial, five injections of Hyalgan given once per week for five weeks reduced knee pain for up to 6 months. Some patients have experienced pain relief after three injections given once per week.
The number of Hyalgan injections you may need will depend on your individual condition and response to Hyalgan therapy. Only your doctor can determine the number of Hyalgan injections suitable for you.
Can I keep taking my other medications?
Yes, after you consult your doctor about the medications, you are currently taking. Hyalgan is a naturally derived product that is delivered via injection. It works differently from pain medications because Hyalgan does not pass through your bloodstream; instead, it works directly in your knee.
In clinical trials, there were no reported drug interactions with Hyalgan.
The most common adverse events reported in clinical trials with Hyalgan included injection-site swelling and irritation. Other adverse events observed included gastrointestinal upset. The incidence of gastrointestinal complaints reported with Hyalgan was similar to those with a placebo.
Can I repeat my treatment with Hyalgan?
Yes, you can safely repeat your treatment with Hyalgan. Studies have shown no serious side effects associated with Hyalgan following up to 30 months of therapy. Please consult your doctor to see if you can benefit from repeat treatments.
Triluron

FAQ Triluron
How is Triluron given?
Your doctor will inject Triluron into your knee
How many injections will I receive?
Triluron will be administered in a convenient 3-injection regimen, with each injection given 1 week apart.
How soon will I feel pain relief?
Your response to Triluron may vary, depending on the severity of your OA, degree of pain, and pre-existing medical conditions.
How long will pain relief last?
Three injections given at weekly intervals can provide most patients with long-lasting pain relief for up to 6 months. The duration of pain relief you experience may vary.
Can I repeat my treatments?
Triluron therapy can be safely repeated if your doctor feels it is appropriate. Please consult your doctor to determine whether you can benefit from repeat treatment.
Can I take other medications?
Triluron has no known drug interactions. However, you should consult with your doctor before taking any other medications while being treated with Triluron.
What about side effects?
Local side effects sometimes seen with Triluron include joint swelling/pain, injection site pain, local skin reactions (rash, ecchymosis), and injection site warmth. Usually, these disappear within a few days of resting and/or applying ice.
Hymovis

FAQ Hymovis
How is Hymovis therapy given?
Your doctor will inject Hymovis into your knee
How many injections will I receive?
Hymovis will be administered in a convenient 2-injection regimen, with each injection given 1 week apart.
How soon will I get pain relief from Hymovis?
Pain relief varies from patient to patient and may depend on the severity of your disease and the intensity of your pain. Speak with your doctor about your concerns and expectations about Hymovis.
Can I repeat my treatment with Hymovis?
Hymovis therapy can be safely repeated if your doctor feels it is appropriate. Please consult with your doctor to determine whether you can benefit from repeat treatment and when your next cycle of Hymovis can be initiated.
Can I continue taking other medications when I am being treated with Hymovis?
Hymovis has no known drug interactions. However, you should consult your doctor before taking other medications while on Hymovis treatment.
What do I need to do after receiving a Hymovis injection?
It is recommended you avoid strenuous activities, such as high-impact sports (tennis or jogging) or prolonged weight-bearing activities (standing), for approximately 48 hours following the injection. You should speak with your doctor regarding the appropriate time to resume such activities.
What are the possible side effects of Hymovis therapy?
Some side effects (also called reactions) may occur with Hymovis treatment. Symptoms such as knee pain, inflammation, reddening, and swelling may appear at the injection site. The occurrence of knee pain after the injection in a clinical study of Hymovis was almost the same for patients receiving saline. Temporary increases in inflammation (redness and swelling) following injections have occurred in some patients with inflammatory joint conditions. If any of these symptoms appear after you receive Hymovis, you should call your doctor.
Other Treatments for Osteoarthritis of the Knee
If you have osteoarthritis, there are several things you can do that do not involve hyaluronate injections. These include the following: Non-drug treatments such as avoiding activities that cause excess pain in your joints, exercise or physical therapy, or drug therapy including pain killers (acetaminophen and narcotics), drugs with reduce inflammation such as aspirin, nonsteroidal anti-inflammatory agents (e.g., ibuprofen and naproxen) or have corticosteroids injected into the knee joint.
Exercise is an essential component of managing OA knee pain. A complete exercise program should include a combination of different types of workouts performed on a regular basis. Exercise may help your OA by keeping joints flexible, increasing muscle strength, and strengthening bones and ligaments. A good workout routine may also help you maintain a healthy weight, have more energy, and sleep better.
Getting started on an exercise program can be tough if you are in pain. It’s best to start slowly and give yourself achievable goals. Keep a positive mindset and make it enjoyable. Below, you will find a few examples of simple knee exercises. These exercises are designed to stretch and strengthen the muscles around your knee. Before beginning, each exercise, read through all of the instructions. While exercising, breathe normally and use smooth movements.
Remember to check with your doctor before starting a new exercise program. Your doctor will help you determine which exercises are best for you, how to warm up safely, and what exercises you should avoid.
Your doctor may refer you to a physical therapist or an occupational therapist. They can teach you about proper body mechanics (for example, how to lift a heavy object), joint protection, saving energy, and methods for relieving pain.
Here are some helpful exercise tips:
- Discuss your exercise plans with your doctor to put together a program that is right for you
- If possible, start your exercise program under the supervision of a physical therapist or qualified athletic trainer
- Choose an exercise program you enjoy and make it part of your regular routine.
- Consider putting a heat pack on your joints before you begin exercising
- Use small, light weights or exercise bands when you begin strengthening exercises
- Go slowly and increase the difficulty of your exercise routine gradually
- If necessary, apply cold packs to sore muscles when you are finished exercising
- Talk to your doctor if your joints become painful, inflamed, or red from exercising. Adjustments to your workout might be necessary.
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