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Visco Supplementation
Alleviate pain in the knee with Hyaluronate injections. Ideal for those with mild to moderate knee OA.
Visco Supplementation
Alleviate pain in the knee with Hyaluronate injections. Ideal for those with mild to moderate knee OA.

Injections for Treating Osteoarthritis of the Knee

When conservative treatments, such as exercise, weight loss, bracing, and medication, do not work well enough, another treatment that may be considered is knee injections with hyaluronate. Hyaluronate is a natural substance found in high amounts in your body’s joint tissue and joint fluid. It acts as a lubricant and shock absorber inside the joint, enabling your knee to work properly.
There are several common hyaluronate injectables:

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Hyalgan

Hyalgan is a kind of hyaluronate injected directly into your knee by your health care provider. Hyalgan is one of several hyaluronates that have been approved to relieve OA knee pain. Hyaluronate is a natural substance found in high amounts in your body’s joint tissue and joint fluid. It acts as a lubricant and shock absorber inside the joint, enabling your knee to work correctly.
Hyalgan is proven to work! For more than 25 years, Hyalgan has helped millions of people worldwide manage their OA knee pain. Hyalgan has been administered more than 50 million times.
Hyalgan is for people who do not get enough relief from simple pain relievers or other conservative therapies, such as exercise and physical therapy. Clinical studies have shown that Hyalgan is an effective pain relief option for patients with mild and moderate-grade knee OA. The use of Hyalgan in combination with exercise has been shown to improve both knee pain and function. Hyalgan use may also allow patients to delay knee surgery.

FAQ Hyalgan

Hyalgan has been proven to provide long-lasting relief of OA knee pain. In a published clinical trial, five injections of Hyalgan given once per week for five weeks reduced knee pain for up to 6 months. Some patients have experienced pain relief after three injections given once per week.


The number of Hyalgan injections you may need will depend on your individual condition and response to Hyalgan therapy. Only your doctor can determine the number of Hyalgan injections suitable for you.

Yes, after you consult your doctor about the medications, you are currently taking. Hyalgan is a naturally derived product that is delivered via injection. It works differently from pain medications because Hyalgan does not pass through your bloodstream; instead, it works directly in your knee.


In clinical trials, there were no reported drug interactions with Hyalgan.
The most common adverse events reported in clinical trials with Hyalgan included injection-site swelling and irritation. Other adverse events observed included gastrointestinal upset. The incidence of gastrointestinal complaints reported with Hyalgan was similar to those with a placebo.

Yes, you can safely repeat your treatment with Hyalgan. Studies have shown no serious side effects associated with Hyalgan following up to 30 months of therapy. Please consult your doctor to see if you can benefit from repeat treatments.

Triluron

Triluron is a viscous solution containing hyaluronate injected directly into your knee that acts like a lubricant and shock absorber. Hyaluronan is a natural substance found in high amounts in your body’s joint tissue and joint fluid.
Triluron may provide up to 6 months of relief from OA knee pain with just three injections. Triluron was shown to provide long-lasting relief from OA knee pain in a clinical study in which patients were given three injections of Triluron once per week for three weeks. Patients felt a 38% reduction in pain from pre-treatment levels after 6 months.
Triluron is used to relieve knee pain due to osteoarthritis for people who do not get enough relief from simple pain medications (e.g., acetaminophen), exercise, and physical therapy. A clinical study has shown that Triluron is an effective treatment option for patients with knee OA pain.
You should not take this product if you have had any previous allergic relations to Triluron or similar material, e.g., hyaluronate products. You should not have an injection into the knee if you have infections or skin diseases around the injection site.

FAQ Triluron

Your doctor will inject Triluron into your knee

Triluron will be administered in a convenient 3-injection regimen, with each injection given 1 week apart.

Your response to Triluron may vary, depending on the severity of your OA, degree of pain, and pre-existing medical conditions.

Three injections given at weekly intervals can provide most patients with long-lasting pain relief for up to 6 months. The duration of pain relief you experience may vary.

Triluron therapy can be safely repeated if your doctor feels it is appropriate. Please consult your doctor to determine whether you can benefit from repeat treatment.

Triluron has no known drug interactions. However, you should consult with your doctor before taking any other medications while being treated with Triluron.

Local side effects sometimes seen with Triluron include joint swelling/pain, injection site pain, local skin reactions (rash, ecchymosis), and injection site warmth. Usually, these disappear within a few days of resting and/or applying ice.

Hymovis

Hymovis is a high molecular weight viscoelastic hyaluronan therapy for osteoarthritis knee pain. Hymovis is intended to provide relief from your osteoarthritis knee pain when simple painkillers, exercise, or physical therapy have failed to give you adequate pain relief. Hymovis, an FDA-approved hyaluronan-based viscosupplement, is a thick gel injection that acts like a lubricant and shock absorber in the knee joint. Hymovis injections may provide up to 6 months of relief from osteoarthritis knee pain for many patients.

FAQ Hymovis

Your doctor will inject Hymovis into your knee

Hymovis will be administered in a convenient 2-injection regimen, with each injection given 1 week apart.

Pain relief varies from patient to patient and may depend on the severity of your disease and the intensity of your pain. Speak with your doctor about your concerns and expectations about Hymovis.

Hymovis therapy can be safely repeated if your doctor feels it is appropriate. Please consult with your doctor to determine whether you can benefit from repeat treatment and when your next cycle of Hymovis can be initiated.

Hymovis has no known drug interactions. However, you should consult your doctor before taking other medications while on Hymovis treatment.

It is recommended you avoid strenuous activities, such as high-impact sports (tennis or jogging) or prolonged weight-bearing activities (standing), for approximately 48 hours following the injection. You should speak with your doctor regarding the appropriate time to resume such activities.

Some side effects (also called reactions) may occur with Hymovis treatment. Symptoms such as knee pain, inflammation, reddening, and swelling may appear at the injection site. The occurrence of knee pain after the injection in a clinical study of Hymovis was almost the same for patients receiving saline. Temporary increases in inflammation (redness and swelling) following injections have occurred in some patients with inflammatory joint conditions. If any of these symptoms appear after you receive Hymovis, you should call your doctor.

If you have osteoarthritis, there are several things you can do that do not involve hyaluronate injections. These include the following: Non-drug treatments such as avoiding activities that cause excess pain in your joints, exercise or physical therapy, or drug therapy including pain killers (acetaminophen and narcotics), drugs with reduce inflammation such as aspirin, nonsteroidal anti-inflammatory agents (e.g., ibuprofen and naproxen) or have corticosteroids injected into the knee joint.


Exercise is an essential component of managing OA knee pain. A complete exercise program should include a combination of different types of workouts performed on a regular basis. Exercise may help your OA by keeping joints flexible, increasing muscle strength, and strengthening bones and ligaments. A good workout routine may also help you maintain a healthy weight, have more energy, and sleep better.
Getting started on an exercise program can be tough if you are in pain. It’s best to start slowly and give yourself achievable goals. Keep a positive mindset and make it enjoyable. Below, you will find a few examples of simple knee exercises. These exercises are designed to stretch and strengthen the muscles around your knee. Before beginning, each exercise, read through all of the instructions. While exercising, breathe normally and use smooth movements.
Remember to check with your doctor before starting a new exercise program. Your doctor will help you determine which exercises are best for you, how to warm up safely, and what exercises you should avoid.
Your doctor may refer you to a physical therapist or an occupational therapist. They can teach you about proper body mechanics (for example, how to lift a heavy object), joint protection, saving energy, and methods for relieving pain.
Here are some helpful exercise tips:
  • Discuss your exercise plans with your doctor to put together a program that is right for you
  • If possible, start your exercise program under the supervision of a physical therapist or qualified athletic trainer
  • Choose an exercise program you enjoy and make it part of your regular routine.
  • Consider putting a heat pack on your joints before you begin exercising
  • Use small, light weights or exercise bands when you begin strengthening exercises
  • Go slowly and increase the difficulty of your exercise routine gradually
  • If necessary, apply cold packs to sore muscles when you are finished exercising
  • Talk to your doctor if your joints become painful, inflamed, or red from exercising. Adjustments to your workout might be necessary.

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I used to sit or lay down almost all the time, now when I wake up I the morning my back is a little achy but goes away within ½ hour. I feel great most all day. I am so much improved I haven’t even used a walker for about a month. I am so grateful for this treatment, I can’t find the words to thank you. Considering my age (80) I feel great!!
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Though I was nervous about my procedure, management and staff brought a lighter image my way that made my time at Water's Edge remarkable. Nurse Judy is AMAZING! God Bless you all.
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I have enjoyed my experience with Waters edge medical, they are taking a personal interest in me and helping me get through my neuropathy issue. I still have a ways to go but I’m sure and have confidence they will continue to help me.
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Great help for my neuropathy. Very compassionate and caring staff.
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I love this office. The staff are so warm and empathetic. I received help with my muscle spasms and inflammation. Would return to the office for treatment if needed. I highly recommend this office and treatments.
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